Subsistema
Docentes Universitário
Regime
Tempo integral
Vínculo
CT em Funções Públicas a termo resolutivo certo
Atividades
Atividades
2024/01/26. Apresentação oral de trabalho. Redox profiling of a cohort of young versus medically assisted aged individuals in the Algarve region. IX Clinical Biochemistry Workshop.
2024/01/26. Apresentação oral de trabalho. Contribution of S-nitrosylation of PDI to the aggregation and toxicity of alpha-synuclein in SH-SY5Y cells. IX Clinical Biochemistry Workshop.
2025/10/06. Apresentação oral de trabalho. Establishing a Redox Profile for Aging: Biomarker-Based Insights from the ALFA Score. 2nd FEBS Redox Medicine Workshop.
2025/07/10. Apresentação oral de trabalho. Modelos Animais em Investigação Biomédica: Uma Estratégia Pedagógica para o Desenvolvimento de Competências Científicas. CNaPPES – Congresso Nacional de Práticas Pedagógicas do Ensino Superior.
2023/04/28. Apresentação oral de trabalho. Como se constrói um mapa do cérebro? . XXX Aniversário do curso de Bioquímica da Universidade do Algarve.
2021/10/07. Apresentação oral de trabalho. Similar abundance of neural stem cells in the sugranular zone of the hippocampus of Acomys Cahirinus and Mus musculus. IV Jornadas ABC.
2021. Apresentação oral de trabalho. ACE2-overexpression protects RPE cells from inflammation and oxidative stress. Pan-American Reserch Day (PARD 2021) .
2019. Apresentação oral de trabalho. Identification of new targets of S-nitrosylation in neurogenic signaling by thiol redox proteomics. SINAL - 10th MEETING in SIGNAL TRANSDUCTION.
2015. Apresentação oral de trabalho. Gene therapy for the treatment of ocular diseases. Jornada Tecnológica (JORTEC) de Química e Bioquímica, Faculdade Ciências Tecnologia – Universidade Nova Lisboa .
2013. Apresentação oral de trabalho. Epithelial-Mesenchymal Transition and Renal Salt-Inducible Kinase1 Expression in Spontaneously Hypertensive Rats. 23th European Meeting on Hypertension and Cardiovascular Protection.
2011. Apresentação oral de trabalho. Age-Related Changes in Renal Oxidative Stress Markers in SHR and WKY Rats. XLI Reunião Anual da Soc Portuguesa de Farmacologia.
2009. Apresentação oral de trabalho. H2O2-induced stimulation of Cl-/HCO3- exchanger activity in SHR cells is associated with oxidation of exchanger thiol groups. XL Reunião Soc Portug Farmac.
2008. Apresentação oral de trabalho. Effect of apocynin on blood pressure and oxidative stress parameters in young WKY and SHR rats. British Pharmacological Society.
2008. Apresentação oral de trabalho. H2O2-induced stimulation of Cl-/HCO3- exchanger activity in SHR cells is associated with activation of MAPK. XXXIX Reunião Anual Soc Portug Farmacologia.
2008. Apresentação oral de trabalho. Effect of Oxidative Stress on a2-AR-Mediated Events in SHR PTE cells. XIIth Workshop of the ESH Young Investigator Initiative Group.
2007. Apresentação oral de trabalho. Oxidative stress plays a permissive role in a1-adrenergic receptor-induced stimulation of the Cl-/HCO3- exchanger in immortalized SHR PTE cells. XXXVIII Reunião Anual da Soc Portuguesa de Farmacologia.
2007. Apresentação oral de trabalho. Involvement of H2O2 in a1-Adrenoceptor-Mediated Stimulation of Cl-/HCO3- Exchanger Activity in Immortalized SHR Proximal, Tubular Epithelial Cells. XI Workshop of the European Society of Hypertension Young Investigator Initiative Group.
2006. Apresentação oral de trabalho. a1-AR Stimulation and Cl-/HCO3- Exchanger Activity in SHR PTE cells. XXXVII Reunião Anual da Soc Portuguesa de Farmacologia .
2004. Apresentação oral de trabalho. Inhibition of Skeletal Muscle S1-Myosin ATPase Activity by the Peroxynitrite-Releasing Agent SIN-1. 2nd Spanish and Portuguese Congress on Free Radicals.
Projetos
Projetos
2021 - Presente. ABC coLAB: ABC Collaborative Laboratory: Integrated Aging and Rejuvenation Solutions. Investigador.
2026/01/01 - 2027/12/31. From Mechanism to Biomarker: Redox Control of Stress Granules as a Neuroregenerative Driver in Alzheimer’s Disease, Bolsa Pereira Monteiro de Apoio à Investigação Translacional em Neurologia (2025). Investigador responsável.
2024 - 2026. T21S-SH – Tackling impaired neurodevelopment in Down Syndrome via identification of S-sulfhydration targets: a new role for the gasotransmitter hydrogen sulfide signaling in neurodevelopment. Investigador.
2022 - 2024. Identification of S-sulfhydration targets in Down Syndrome: the role of gasotransmitter hydrogen sulfide (H2S) signaling in neurodevelopment. Investigador.
2022 - 2024. SNO-PD: Contribution of S-Niitrosylation for the aggregation of alfa-synuclein in Parkinson's disease. Investigador.
2021 - 2024. ALgarve Fit Ageing (ALFA) Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável. Investigador. Algarve Biomedical Center Research Institute - ABC-RI.
2020 - 2022. SPINY: Identifying and Modulating the Mechanisms Responsible for Functional Recovery and Axon Regeneration of the Injured Acomys Spinal Cord, Prémios Santa Casa Neurociências 2019, Prémio Melo e Castro. Investigador.
2018 - 2021. GT-LightUP: Signaling Gasotransmitters Light Up. Investigador. Universidade de Aveiro.
2014/01/01 - 2015. RASRET - Role of the renin-angiotensin system in retinal diseases and its therapeutic potential. Co-Investigador Responsável (Co-IR). Universidade do Algarve.
2010 - 2013. Regulatory effects of pattern recognition receptors (prrs) in electrolyte transport and membrane potential in intestinal epithelial cells. Investigador. Universidade do Porto.
2007 - 2010. Oxidative stress and genetic markers of cardiovascular risk in hypertension. Investigador. Universidade do Porto.
2004 - 2007. Antinatriuretic agents and the renal bicarbonate handling in hypertension. Bolseiro de Investigação. Universidade do Porto.
Produções
Agostinho, Rafaela; Simão, Sónia; Martínez-Ruiz, Antonio; Araújo, Inês Maria. 2026. "Dimedone Switch Method in Induced Pluripotent Stem Cells". Em Methods in Molecular Biology. Springer Nature.
Agostinho, Rafaela; Calado, Sofia M.; Bragança, José; Nzwalo, Hipólito; Marques, Vera Mascarenhas; Bota, Mónica; Medeiros, Raquel Melo; et al. 2026. "Establishment and characterization of induced pluripotent stem cell lines from individuals with down syndrome and age-matched euploid donors". Stem Cell Research. https://doi.org/10.1016/j.scr.2026.103932
De Sousa-Coelho, Ana Luísa; Araújo, Inês Maria; Simão, Sónia. Autor correspondente: Simão, Sónia. 2026. "Liver–Brain Crosstalk in Obesity: Linking Metabolic Dysfunction to Neurodegeneration". Biomolecules .
Simão, Sónia; Santos, Daniela F.; Teixeira, Mariana; Agostinho, Rafaela R.; Rodrigues, Joana; Vitorino, Marta; Araújo, Inês M.. Autor correspondente: Simão, Sónia. 2025. "Unraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer’s and Parkinson’s diseases". Redox Report, 31 (1). https://doi.org/10.1080/13510002.2025.2592413
Teixeira, Mariana; Simão, Sónia; Outeiro, Tiago; Araújo, Inês Maria. 2025. Identification of S-nitrosylation targets contributing to pathological aggregation of alpha-synuclein in Parkinson´s disease: a proteomic study. Em Encontro Ciência 2025.
Agostinho, Rafaela; Teixeira, Mariana; MASCARENHAS MARQUES, VERA; Martínez-Ruiz, Antonio; Simão, Sónia; Araújo, Inês Maria. 2025. Optimization of Dimedone Switch Method for detection of S-sulfhydrated proteins in human induced pluripotent stem cells derived from Down syndrome individuals. Em 2nd FEBS Redox Medicine Workshop.
Teixeira, Mariana; Agostinho, Rafaela R.; Martínez-Ruiz, Antonio; Outeiro, Tiago; Araújo, Inês Maria; Simão, Sónia. 2025. Identification of S-nitrosylation targets contributing to pathological aggregation of alpha-synuclein in Parkinson´s Disease: a proteomic study. Em 2nd FEBS Redox Medicine Workshop.
Conceição, Natércia; Simão, Sónia; Araújo, Inês Maria. "Modelos Animais em Investigação Biomédica: Uma Estratégia Pedagógica para o Desenvolvimento de Competências Científicas". CNaPPES , 2025.
Simão, Sónia. 2024. Characterization of Adult Neurogenesis in Acomys cahirinus by Lineage Tracing Analysis. Em IX Clinical Biochemistry Workshop.
Simão, Sónia. 2024. Dysregulation of H2S levels in a cellular model of Down Syndrome. Em IX Clinical Biochemistry Workshop.
Santos, Daniela F.; Simão, Sónia; Nóbrega, Clévio; Bragança, José; Castelo-Branco, Pedro; Araújo, Inês M.; ALFA Score Consortium. 2024. "Oxidative stress and aging: synergies for age related diseases". FEBS Letters. https://doi.org/10.1002/1873-3468.14995
Santos, Daniela F.; Simão, Sónia; Araújo, Inês Maria. 2024. Oxidative profile of a cohort of young versus aged individuals in the Algarve region. Em HEAT-NET Frontiers in Neurodegeneration: from bench to bedside.
Esteves, Filipa; Vilhena Catarino Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia; Andrade, Raquel; et al. 2024. "Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research". Stem Cell Research, 81. https://doi.org/10.1016/j.scr.2024.103576
Agostinho, Rafaela; MARQUES, VERA; Sofia M. Calado; Bragança, José; Nzwalo, Hipólito; Mónica Bota; Raquel Melo Medeiros; et al. 2024. Cystathionine beta-synthase and H2S levels are increased in cellular models of trisomy 21. Em FENS Forum 2024.
D V C, Brito; F, Esteves; A T, Rajado; N, Silva; I, Araújo; J, Bragança; P, Castelo-Branco; A, Sardo; Simão, Sónia. 2023. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies.". npj aging, 9.
Filipa Esteves; David Brito; Ana Teresa Rajado; Nádia Silva; Joana Apolónio; Vânia Palma Roberto; Inês Araújo; et al. 2023. "Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials". Mechanisms of Ageing and Development, 214. https://doi.org/10.1016/j.mad.2023.111854
Silva, Nádia; Rajado, Ana Teresa; Esteves, Filipa; Brito, David V.C.; Apolónio, Joana; Roberto, Vânia; Binnie, Alexandra; et al. 2023. "Measuring healthy ageing: current and future tools". Biogerontology, 24 (6).
Simão, Sónia; Agostinho, Rafaela Ribeiro; Martínez-Ruiz, Antonio; Araújo, Inês Maria. Autor correspondente: Simão, Sónia. 2023. "Regulation of Ras Signaling by S-Nitrosylation". Antioxidants, 12 (8). https://doi.org/10.3390/antiox12081562
Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David; Binnie, Alexandra; Araújo, Inês M.; Nóbrega, Clévio; et al. 2023. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging. https://doi.org/10.18632/aging.204668
Santos, Carla I.M.; Santiago, Ana M.; Araújo, Ana R.L.; Pinto, Sandra; Agostinho, Rafaela R.; Simão, Sónia; Azevedo, Tomás P.; et al. 2023. "New fluorescent probes based on gallium(III) corrole complexes for the recognition of hydrogen sulfide: A journey from solution to intracellular site". Dyes and Pigments, 216. https://doi.org/10.1016/j.dyepig.2023.111304
Simão, Sónia. 2023. Brain Atlas of Acomys cahirinus: Creating tools to study brain regeneration. Em VII Symposium Portuguese Glial Network.
Simão, Sónia. 2023. New model of brain disorders in Acomys cahirinus: from brain mapping to accurate stereotaxic coordinates. Em FENS Regional Meeting.
Simão, Sónia. 2023. Characterization and modulation of H2S production in fibroblasts derived from Down Syndrome individuals by time-lapse fluorescence imaging. Em FENS Regional Meeting.
Simão, Sónia. 2023. Redox profiling of a cohort of young versus old individuals in the Algarve region. Em 1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets.
Simão, Sónia. 2023. Illuminating Neurogenesis: Unveiling Acomys cahirinus newborn neurons by lineage tracing imaging. Em Spanish & Portuguese Advanced Optical Microscopy Meeting .
Simão, Sónia. 2023. Assessment of H2S production in fibroblasts by time-lapse fluorescence imaging prior to establishment of fibroblast-derived iPS cell lines. Em Spanish & Portuguese Advanced Optical Microscopy Meeting .
Santos, Daniela F.; Simão, Sónia; Silva, Nádia; Brito, David V.C.; Clévio Nobrega; Bragança, José; Pedro Castelo-Branco; Araújo, Inês Maria. 2023. Redox profiling of a cohort of young versus medically assisted aged individuals in the Algarve region.. Em 1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets.
Nogueira-Rodrigues, Joana; Leite, Sérgio C.; Pinto-Costa, Rita; Sousa, Sara C.; Luz, Liliana L.; Sintra, Maria A.; Oliveira, Raquel; et al. 2022. "Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection". Developmental Cell, 57 (4): 440-450.e7. https://doi.org/10.1016/j.devcel.2021.12.008
Vitorino, Marta; Simão, Sónia; Moreira, João B.; Nogueira-Rodrigues, Joana; Silva, Joana; Lourenço, Ana Sofia; Fernandes, Vítor; et al. 2022. "Coronal brain atlas in stereotaxic coordinates of the African spiny mouse, Acomys cahirinus". Journal of Comparative Neurology, 530 (12): 2215-2237. https://doi.org/10.1002/cne.25329
Simão, Sónia. 2022. Brain Atlas of Acomys cahirinus: a new tool for regenerative studies. Em Ageing without borders.
Rajado, Ana Teresa; Raquel P. Andrade; Apolónio, Joana ; Inês Maria Pombinho de Araújo; Brito, David V.C.; Sofia M. Calado; Esteves, Filipa; et al. 2022. ALFA Score - Algarve Fit Ageing Score. Em ABC-Days.
Bitoque, Diogo B.; Morais, Joana; Oliveira, Ana V.; Sequeira, Raquel L.; Calado, Sofia M.; Fortunato, Tiago M.; Simão, Sónia; Rosa da Costa, Ana M.; Silva, Gabriela A.. 2021. "Human-derived NLS enhance the gene transfer efficiency of chitosan". Bioscience Reports, 41 (1). https://doi.org/10.1042/bsr20201026
Simão, Sónia. 2021. ACE2-overexpression protects RPE cells from inflammation and oxidative stress. Em 2021 ARVO Annual Meeting.
Simão, Sónia. "Como é que a formação de novos neurónios é estimulada a seguir a uma lesão cerebral provocada por crises epilépticas?". UALgoritmo: a ciência trocada por miúdos, 2021.
Simão, Sónia. 2021. New corrole-based H2S fluorescent probes for time-lapse imaging in cultured cells. Em IV Jornadas Algarve Biomedical Center.
Simão, Sónia. 2021. Rewired glycosyltransferase activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection. Em Encontro Ciência 2021.
Simão, Sónia. 2021. "ACE2-overexpression protects RPE cells from inflammation and oxidative stress". Trabalho apresentado em 2021 ARVO Annual Meeting, 62.
Santos, Ana Isabel; Lourenço, Ana Sofia; Simão, Sónia; Marques da Silva, Dorinda; Santos, Daniela Filipa; Onofre de Carvalho, Ana Paula; Pereira, Ana Catarina; et al. 2020. "Identification of new targets of S-nitrosylation in neural stem cells by thiol redox proteomics". Redox Biology, 32. https://doi.org/10.1016/j.redox.2020.101457
Simão, Sónia. 2018. "Peroxynitrite versus decavanadate protein oxidative modifications: the case of myosin". Trabalho apresentado em 19th biennial meeting for the Society for Free Radical Research International (SFRRI), Lisboa, Portugal, 120 (1).
Simão, Sónia. 2018. Peroxynitrite versus decavanadate protein oxidative modifications: the case of myosin. Em 19th biennial meeting for the Society for Free Radical Research International (SFRRI).
Simão, Sónia; Santos, Daniela F.; Silva, Gabriela A.. 2017. "Aliskiren decreases oxidative stress and angiogenic markers in retinal pigment epithelium cells". Angiogenesis, 20 (1): 175-181. https://doi.org/10.1007/s10456-016-9526-5
Simão, Sónia. 2017. "Deregulation of the retinal renin-angiotensin system precedes the onset of diabetic retinopathy". Trabalho apresentado em 53rd EASD Annual Meeting, Lisboa, Portugal, 60 (1).
Simão, Sónia. 2017. Deregulation of the retinal renin-angiotensin system precedes the onset of diabetic retinopathy. Em 2nd Annual CBMR Meeting.
Simão, Sónia; Santos, Daniela F.; Silva, Gabriela A.. 2016. "Aliskiren inhibits the renin-angiotensin system in retinal pigment epithelium cells". European Journal of Pharmaceutical Sciences, 92: 22-27. https://doi.org/10.1016/j.ejps.2016.06.019
Simão, Sónia. 2016. "Oxidative stress modulates the expression of VEGF isoforms in the diabetic retina". New Frontiers in Ophthalmology, 2 (1): 77-83. https://oatext.com/Oxidative-stress-modulates-the-expression-of-VEGF-isoforms-in-the-diabetic-retina.php
Simão, Sónia. 2016. "GLUT1 activity contributes to the impairment of PEDF secretion by the RPE". Molecular Vision, 22: 761-770. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943856/
Simão, Sónia. 2016. "Increased expression of (pro)renin and (pro)renin receptor correlates with the progression of diabetic retinopathy". Trabalho apresentado em 16th EURETINA Congress, copenhaga, Dinamarca, 236 (1), 1-67.
Simão, Sónia. 2016. Hyperglycemia modulates the renin-angiotensin system in retinal pigment epithelial cells. Em 1st Annual CBMR Meeting.
Simão, Sónia. 2016. Identification of neurogenic S-nitrosylation targets in neural stem cells. Em 1st Annual CBMR Meeting.
Sofia M. Calado; Simão, Sónia; B Bitoque, Diogo; M Calado, Sofia; A Silva, Gabriela. 2016. "Oxidative stress modulates the expression of VEGF isoforms in models of diabetic retinopathy". New Frontiers in Ophthalmology, 2 (2). https://doi.org/10.15761/NFO.1000119
Simão, Sónia. 2015. "Hyperglycemia and hypoxia induce overexpression of GLUT1 in models of Diabetic Retinopathy". Trabalho apresentado em 51st EASD Annual Meeting, estocolmo, Suécia, 58 (1).
Simão, Sónia. 2015. "The role of GLUT1 in the pathogenesis of Diabetic Retinopathy". Trabalho apresentado em ESGCT and FSGT Collaborative Congress, Elsinquia, Finlândia, 26.
Bitoque, Diogo B.; Simão, Sónia; Oliveira, Ana V.; Machado, Susana; Duran, Margarita R.; Lopes, Eduardo; da Costa, Ana M. Rosa; Silva, Gabriela A.. 2014. "Efficiency of RAFT-synthesized PDMAEMA in gene transfer to the retina". Journal of Tissue Engineering and Regenerative Medicine, 11 (1): 265-275. https://doi.org/10.1002/term.1909
Simão, Sónia. 2014. "Anti-angiogenic VEFG isoform is markedly decreased in the retina of diabetic mice". Trabalho apresentado em ESGCT and NVGCT Collaborative Congress, Haia, Países Baixos, 25 (11), A107-A108.
Simão, Sónia. 2014. "Insights on the role of the Renin-Angiotensin System in diabetic retinopathy". Trabalho apresentado em ESGCT and NVGCT Collaborative Congress, Haia, Países Baixos, 25 (11).
Simão, Sónia. 2014. "Renin is expressed in D407 human retinal cells". Trabalho apresentado em European Society of Hypertension and International Society of Hypertension, Atenas, Grécia, 32 (1).
Simão, Sónia; Gomes, Pedro; Pinho, Maria João; Soares-da-Silva, Patrício. 2013. "Identification of SLC26A transporters involved in the Cl-/HCO3- exchange in proximal tubular cells from WKY and SHR". Life Sciences, 93 (12-14): 435-440. https://doi.org/10.1016/j.lfs.2013.07.026
Gomes, Pedro; Simão, Sónia; Lemos, Vera; Amaral, João S.; Soares-da-Silva, Patrício. 2013. "Loss of oxidative stress tolerance in hypertension is linked to reduced catalase activity and increased c-Jun NH2-terminal kinase activation". Free Radical Biology and Medicine, 56: 112-122. https://doi.org/10.1016/j.freeradbiomed.2012.11.017
Simão, Sónia. 2013. "Glucose and H2O2 modulate the expression of VEGF isoforms in human retinal cells". Trabalho apresentado em ESGCT and SETGC Collaborative Congress , Madrid, Espanha, 24 (12).
Simão, Sónia. 2013. "Carotenoid-based lipoplexes efficiently transfect retinal pigment epithelium cells". Trabalho apresentado em ESGCT and SETGC Collaborative Congress , Madrid, Espanha, 24 (12).
Simão, Sónia. 2013. "pEPito-based vectors enable long-term expression in mouse models of diabetic retinopathy". Trabalho apresentado em ESGCT and SETGC Collaborative Congress, Madrid, Espanha, 24 (12).
Simão, Sónia. 2013. Hybrid strategies for retinal gene therapy. Em 8th Intern Meeting of the Portuguese Soc. Stem Cells & Cell Therapies.
Pinto, Vanda; Pinho, Maria João; Silva, Elisabete; Simão, Sónia; Igreja, Bruno; Afonso, Joana; Serrão, Maria Paula; Gomes, Pedro; Soares-da-Silva, Patrício. 2012. "Long-term food restriction attenuates age-related changes in the expression of renal aldosterone-sensitive sodium transporters in Wistar-Kyoto rats: A comparison with SHR". Experimental Gerontology, 47 (8): 644-653. https://doi.org/10.1016/j.exger.2012.05.022
Simão, Sónia. 2012. "H2O2 modulates the expression of VEGF isoforms in retinal cells". Trabalho apresentado em ESGCT and SFTCG Collaborative Congress , Versailles, França, 23 (10).
Simão, Sónia. 2012. Activation of the aldosterone/MR system by aging in spontaneously hypertensive rats. Em European Society of Hypertension (ESH) 2012: 22nd European Meeting on Hypertension and Cardiovascular Protection.
Simão, Sónia; Gomes, Pedro; Pinho, Maria João; Soares-da-Silva, Patrício. 2011. "H2O2 stimulates Cl-/HCO¿3- exchanger activity through oxidation of thiol groups in immortalized SHR renal proximal tubular epithelial cells". Journal of Cellular Biochemistry, 112 (12): 3660-3665. https://doi.org/10.1002/jcb.23299
Pinto, Vanda; Amaral, João; Silva, Elisabete; Simão, Sónia; Cabral, José Miguel; Afonso, Joana; Serrão, Maria Paula; et al. 2011. "Age-related changes in the renal dopaminergic system and expression of renal amino acid transporters in WKY and SHR rats". Mechanisms of Ageing and Development, 132 (6-7): 298-304. https://doi.org/10.1016/j.mad.2011.06.003
Simão, Sónia; Gomes, Pedro; Pinto, Vanda; Silva, Elisabete; Amaral, João S.; Igreja, Bruno; Afonso, Joana; et al. 2011. "Age-related changes in renal expression of oxidant and antioxidant enzymes and oxidative stress markers in male SHR and WKY rats". Experimental Gerontology, 46 (6): 468-474. https://doi.org/10.1016/j.exger.2011.02.003
Simão, Sónia. 2011. "H2O2 Increases Cl-/HCO3- Exchanger Activity through Oxidation of Thiol Groups in Spontaneously Hypertensive Rats Renal Cells". Trabalho apresentado em Annual High Blood Pressure Research Conference, Orlando, Estados Unidos, 58 (5).
Simão, Sónia. 2011. "Isolated Systolic Hypertension in Old WKY Rats is Associated With Oxidative Stress and Metabolic Derangements: Effect of Dietary Restriction". Trabalho apresentado em Annual High Blood Pressure Research Conference, Orlando, Estados Unidos, 58 (5).
Simão, Sónia. 2011. "Slc26 Transporters Involved in Cl-/HCO3- Exchange Activity in Wistar Kyoto and Spontaneously Hypertensive Rats Proximal Tubular Epithelial Cells". Trabalho apresentado em Annual High Blood Pressure Research Conference, Orlando, Estados Unidos, 58 (5).
Simão, Sónia. 2011. "The Renal Dopaminergic System and Amino Acid Transporter Expression in Aged WKY and SHR Rats". Trabalho apresentado em European Meeting on Hypertension, Milan, Itália, 29.
Simão, Sónia. 2011. "Enhanced Susceptibility to Oxidative Stress Induced Cell Death in SHR is Linked to Reduced Catalase Activity and Increased JNK Activation". Trabalho apresentado em European Meeting on Hypertension, Milan, Itália, 29.
Simão, Sónia. 2011. "Regulation of CI/HCO3 Exchanger in a Genetic Model of Hypertension". Doutoramento.
Silva, E.; Pinto, V.; Simão, S.; Serrão, M.P.; Afonso, J.; Amaral, J.; Pinho, M.J.; Gomes, P.; Soares-da-Silva, P.. 2010. "Renal aging in WKY rats: Changes in Na+,K+-ATPase function and oxidative stress". Experimental Gerontology, 45 (12): 977-983. https://doi.org/10.1016/j.exger.2010.09.012
Simão, S.; Gomes, P.; Jose, P.A.; Soares-da-Silva, P.. 2010. "Increased responsiveness to JNK1/2 mediates the enhanced H2O2-induced stimulation of Cl-/HCO3- exchanger activity in immortalized renal proximal tubular epithelial cells from the SHR". Biochemical Pharmacology, 80 (6): 913-919. https://doi.org/10.1016/j.bcp.2010.05.013
Simão, Sónia. 2010. Increased Responsiveness to JNK1/2 Mediates the Enhanced H2O2-Induced Stimulation of Cl-/HCO3- Exchanger Activity in SHR PTE cells. Em 4thNational Meeting on Signal Transduction SINAL.
Gomes, Pedro; Simão, Sónia; Silva, Elisabete; Pinto, Vanda; Amaral, João S.; Afonso, Joana; Serrão, Maria Paula; Pinho, Maria João; Soares-da-Silva, Patrício. 2009. "Aging increases Oxidative Stress and Renal Expression of Oxidant and Antioxidant Enzymes that Are Associated with an Increased Trend in Systolic Blood Pressure". Oxidative Medicine and Cellular Longevity, 2 (3): 138-145. https://doi.org/10.4161/oxim.2.3.8819
Simão, S; Fraga, S; Jose, P A; Soares-da-Silva, P. 2009. "Oxidative stress and a1-adrenoceptor-mediated stimulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells". British Journal of Pharmacology, 153 (7): 1445-1455. https://doi.org/10.1038/bjp.2008.16
Simão, Sónia. 2009. "Oxidative stress and renal mineralcorticoid receptor expression in aged wistar kyoto (WKY) and spontaneously hypertensive (SHR) rats". Trabalho apresentado em 19th European Meeting on Hypertension, Milan, Itália, 27 (4).
Simão, Sónia. 2009. "Lack of effect of antioxidant therapy with apocynin, a NADPH oxidase inhibitor, against oxidative stress and elevated blood pressure in SHR rats". Trabalho apresentado em 19th European Meeting on Hypertension, Milan, Itália, 27 (4).
Simão, Sónia. 2009. "Aging and Na,K-ATPase activity and expression in kidney and jejunum of normotensive and spontaneously hypertensive rats". Trabalho apresentado em 19th European Meeting on Hypertension, Milan, Itália, 27 (4).
Simão, Sónia. 2009. "Differences in H2O2-Induced Stimulation of Cl-/HCO3- Exchanger Activity in WKY and SHR Immortalized Renal Proximal Tubular Cells". Trabalho apresentado em 19th European Meeting on Hypertension, Milan, Itália, 27 (4).
Simão, Sónia. 2009. "Unique Profile In Renal Mineralocorticoid Receptor Expression Change In Aged Spontaneously Hypertensive Rats". Trabalho apresentado em 63rd Annual High Blood Pressure Research Conference, Chicago, Estados Unidos, 54 (4).
Simão, Sónia. 2009. "Effect Of Food Restriciton Upon Mineralocorticoid Receptor Expression And Function In Young And Aged Wistar Kyoto Rats". Trabalho apresentado em 63rd Annual High Blood Pressure Research Conference, Chicago, Estados Unidos, 54 (4).
Simão, Sónia; Fraga, Sónia; Jose, Pedro A.; Soares-da-Silva, Patrício. 2008. "Oxidative stress plays a permissive role in a2-adrenoceptor-mediated events in immortalized SHR proximal tubular epithelial cells". Molecular and Cellular Biochemistry, 315 (1-2): 31-39. https://doi.org/10.1007/s11010-008-9785-6
Simão, Sónia; Pedrosa, Rui; Hopfer, Ulrich; Mount, David B.; Jose, Pedro A.; Soares-da-Silva, Patrício. 2008. "Short-term regulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells". Biochemical Pharmacology, 75 (11): 2224-2233. https://doi.org/10.1016/j.bcp.2008.03.003
Pedrosa, Rui; Villar, Van Anthony M.; Pascua, Annabelle M.; Sima~o, So´nia; Hopfer, Ulrich; Jose, Pedro A.; Soares-da-Silva, Patri´cio. 2008. "H
2
O
2
Stimulation of the Cl
-
/HCO
3
-
Exchanger by Angiotensin II and Angiotensin II Type 1 Receptor Distribution in Membrane Microdomains". Hypertension, 51 (5): 1332-1338. https://doi.org/10.1161/hypertensionaha.107.102434
2
O
2
Stimulation of the Cl
-
/HCO
3
-
Exchanger by Angiotensin II and Angiotensin II Type 1 Receptor Distribution in Membrane Microdomains". Hypertension, 51 (5): 1332-1338. https://doi.org/10.1161/hypertensionaha.107.102434
Simão, Sónia. 2008. "Resistance of immortalized renal cells from WKY and SHR rats to oxidative stress is associated with activation of multiple MAPK signaling pathways". Trabalho apresentado em 18th European Meeting on Hypertension, Berlin, Alemanha, 26 (1).
Simão, Sónia. 2008. "Oxidative Stress Plays a Permissive Role in a1-AR-Induced Stimulation of Cl-/HCO3- Exchanger in Immortalized SHR Proximal Tubular Epithelial Cells". Trabalho apresentado em 18th European Meeting on Hypertension, Berlin, Alemanha, 26 (1).
Simão, Sónia. 2008. Increased susceptibility of renal cells from SHR to H2O2 is associated with activation of multiple MAPK signaling pathways and impaired antioxidant/oxidant balance. Em Gordon Research Conferences – Oxigen Radicals.
Simão, Sónia. 2007. "Involvement of H2O2 in Norepinephrine-Induced Stimulation of Cl-/HCO3- Exchanger Activity in Immortalized SHR Cells". Trabalho apresentado em 61st Annual High Blood Pressure Research Conference, Tucson, Estados Unidos, 50 (4).
Simão, Sónia. 2007. "Norepinephrine-Induced Stimulation of Cl-/HCO3- Exchanger Activity through alpha1-Adrenergic Receptors in Immortalized Proximal Tubular Epithelial Cells from Spontaneously Hypertensive Rats". Trabalho apresentado em 17th European Meeting on Hypertension, Milan, Itália, 25 (2).
Simão, Sónia. 2007. "a2-AR Stimulation and Cl-/HCO3- Exchanger Activity in Immortalized Proximal Tubular Epithelial Cells from Spontaneously Hypertensive Rats". Trabalho apresentado em 17th European Meeting Hypertension, Milan, Itália, 25 (2).
Simão, Sónia. 2007. "Oxidative Stress and a2-Adrenoceptor-mediated Events in Immortalized Proximal Tubular Epithelial Cells from the Spontaneously Hypertensive Rat". Trabalho apresentado em 61st Annual High Blood Pressure Research Conference, Tucson, Estados Unidos, 50 (4).
Tiago, Teresa; Simão, Sónia; Aureliano, Manuel; Martín-Romero, Francisco Javier; Gutiérrez-Merino, Carlos. 2006. "Inhibition of Skeletal Muscle S1-Myosin ATPase by Peroxynitrite". Biochemistry, 45 (11): 3794-3804. https://doi.org/10.1021/bi0518500
Simão, Sónia. 2006. "Role of PKC on the regulation of enhanced Cl-/HCO3- exchanger activity in hypertension". Trabalho apresentado em XLIII ERA-EDTA Congress, Glasgow, Reino Unido, 21 (4).
Simão, Sónia. 2006. "Norepinephrine and Cl-/HCO3- Exchanger Activity in Immortalized SHR cells". Trabalho apresentado em XLIII ERA-EDTA Congress, Glasgow, Reino Unido, 21 (4).
Simão, Sónia. 2004. "Suscepibility of S1 fragment of myosin from rabbit skeletal muscle to peroxynitrite". Licenciatura.
Simão, Sónia. 2004. Skeletal Muscle Myosin-S1 Susceptibility to Peroxynitrite. Em XIV Congresso Nacional de Bioquímica. https://doi.org/10.1183/13993003.congress-2019.pa4309
Simão, Sónia. 2003. Free-Radical Mediated Effects on Myosin and Actin from Skeletal Muscle. Em 1st Luso-Spanish Congress on Free Radicals, 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine.
